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By a year later, women who were taking compounded hormones reported significantly less depression, anxiety, and pain. The pharmacist typically places the cream in plastic syringes that contain the precise amount a woman needs each day, she says. While androgens

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are often labeled "male hormones," they're necessary for women's health,

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is needed," she tells. Half were given conventional hormone pills -- birth control pills for younger women and Prempro (estrogen plus progesterone) or Premarin (estrogen

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only) for the menopausal women. The other

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half received a cream that contained a customized blend of some combination of estrogen, progesterone, and the androgens testosterone and DHEA. They had fewer hot flashes and night sweats. The researchers studied custom-compounded creams

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made from plant-derived hormones that are biochemically similar to those produced by the body. The

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new research suggests that these compounds "can make remarkable changes in a woman's life," says Kenna Stephenson, MD, of the University of

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Texas Health Science Center at Tonnie. A deficiency has been linked to menopausal symptoms, loss of libido, and other problems, Stephenson notes. Blood pressure and

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triglyceride levels fell. Custom-compounded hormones have been gaining favor ever since a large government-funded study known as the Women's Health Initiative linked the long-term use of conventional hormone replacement therapy in menopausal women to an increased risk of heart disease, stroke, and breast cancer. A preparation contains one or more various hormones in different

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amounts to meet each woman's individualized needs. In contrast, conventional hormone pills have been shown to raise triglyceride and CRP levels, says Nieca Goldberg, MD, an American Heart Association spokeswoman and heart specialist at Lenox Hill Hospital in New York City. Their quality of life improved. Stephenson says women who want to use the hormonal blends need to make sure they choose a compounding pharmacist who

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is licensed and trained. Custom Creams Improve Menopause Symptoms The 12-month study involved 150 perimenopausal and postmenopausal women 30 to 70. As an added benefit, they may also improve heart health, researchers

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say. Levels of C-reactive protein (CRP) and other markers of harmful inflammation in the arteries that can lead to blood clots dropped as well. But there have been few well designed studies showing the custom-compounded hormone preparations actually work. "Individualized hormonal treatments are just what women need," she tells. The International Academy of Compounding Pharmacists, which helped fund the research, maintains a list of members with specialized training, she says..